![]() Genes are inactivated by gene deletion, promoter methylation, frame shift, aberrant splicing although point mutations for theĬoding region affect only the latter. Is more efficient for the for the former than the latter in the mouse system. ![]() The efficiency of detection of oncogenic signals Incipient cancer cell signals, and thus these two gene functions are different. ARF has been shown to monitor potentially harmful oncogenic signalings, making early stage cancerĬells undergo senescence or programmed cell death to prevent cancer. ![]() The ARF and INK4a genes are located on the CDKN2a locus, both showing
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